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Common Symptom Guide

Depression That Hasn't Responded to Standard Treatment? There's More to Try.

When typical antidepressants haven't worked, treatment-resistant options exist — under real physician supervision.

Reviewed by Dr. Justin Abbott, D.O. — ABFM Board-Certified Physician
★★★★★5.0 from 38 Google reviews
ABFM Board Certified Evidence-Based Care Personalized Treatment Plans
When Standard Treatment Isn't Enough

When Standard Treatment Isn't Enough

Depression affects everyone differently, and not everyone responds to standard antidepressant medications. For some patients, the standard first- and second-line treatments simply don't provide adequate relief.

Depression can also overlap with hormone imbalance and thyroid dysfunction, which is why a full evaluation matters before assuming the picture is purely psychiatric.

Common Depression Symptoms

Persistent low mood or loss of interest
Fatigue or low energy
Difficulty concentrating
Changes in sleep or appetite
Feelings of hopelessness
Depression that hasn't improved with standard medications
How We Approach It

A Broader Set of Options

For treatment-resistant depression, ketamine therapy offers a different mechanism than traditional antidepressants, often producing results within days rather than weeks. We also rule out physiological contributors.

Physician Insight

"Treatment-resistant depression is exactly what it sounds like — the standard options were tried, and they didn't do enough. That's when I think ketamine deserves a real conversation."

★★★★★

“Dr. Abbott and his team are very attentive and friendly. He listens to any concerns I have and gives thoughtful suggestions and solutions to my specific needs.”

— Lindsey J., Google review

Common Questions

Depression FAQs

What patients ask most before their first appointment.

Depression is generally considered treatment-resistant when it hasn't responded adequately to at least two different antidepressant medications, tried at appropriate doses for an adequate length of time.
Ketamine works through a different mechanism in the brain and often produces improvement within hours to days, compared to the weeks or months standard antidepressants can take.
Yes, hormone imbalance and thyroid dysfunction can contribute to or worsen depressive symptoms. A comprehensive evaluation helps determine whether physiological factors are part of the picture.
Get Started

If Standard Treatment Hasn't Worked, Let's Talk About What's Next.

A thorough evaluation and a real conversation with Dr. Abbott about what's next.